Endocrine Abstracts

Objectives: Coexistence of two different malignancies is frequently reported. Sometimes occurs in the context of well-established syndromes like MEN2. Rearranged during transfection (RET), is an oncogenic driver activated in different kinds of neoplasias such as: MTC, Differentiated Thyroid Cancer (DTC), Non-Small Cell Lung Cancer (NSCLC). We have previously reported an increased prevalence of DTC in familial MTC patients carrying the RET (G533C) mutation. Ai...

Introduction: The association of thyroid disorders including autoimmune thyroiditis with the risk for breast cancer is controversial (1–4). A recent study found that triidothyronine (T3) levels are positively associated with breast cancer specific mortality (5). Experimental studies have shown that T3 mimics the effects of estrogen in human breast cell lines and induces the expression of progesterone receptors (6).Purpose: The ...

Background and aims: Gestational diabetes (GD) is closely related to unbalanced zinc (Zn) and cooper (Cu) serum levels. The aim of this study was to investigate serum zinc and cooper levels in relation to the metabolic profile, and the impact on fetal development in a cohort of gestational diabetes GD(N) neonates and their mothers GD(M) compared to normal pregnancies.Material and Methods: Prospective controlled study in a tertiary Academic medical center...

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

Introduction: In recent years, micro papillary thyroid carcinomas (mPTCs; ≤1.0 cm) are increasingly diagnosed. Although clinical course is usually favourable, disease persistence may occur and multiple treatments needed. We examined factors that could be predictors of clinical behaviour and disease persistence.Patients and methods: 478 mPTC patients (78.9% females) followed-up for 0.6–10 years were classified according to tumour size in group ...

Introduction: The relation between vitamin D deficiency and gestational diabetes mellitus (GDM) has been rarely addressed in the literature with conflicting results. The aim is to determine the association between maternal serum 25(OH)D and glucose metabolism in Caucasian pregnant women.Patients and methods: In a prospective study 157 pregnant women aged 31.2±5.8 years underwent a 100 g OGTT in the third trimester of pregnancy, during which serum 25...

Background: Swyer syndrome is a type of pure gonadal dysgenesis 46 XY caryotype in phenotypically female patients. A rare case of Swyer syndrome complicated by dysgerminoma and Retiform Sertoli-Leydig cell’s tumor is reported.Case presentation: A 20-year-old phenotypically female patient presented to our department with primary amenorrhea. She was 1.68 m and weighed 82 kg (BMI 28). She presented with minimal breast development, sparse axillary and p...

Objectives: The interplay between thyroid function and metabolic state has been studied in many population subgroups. For pregnant women thyroid and metabolic parameters, including glucose homeostasis, are of great importance for a successful outcome. We examined aspects of thyroid function in relation to GDM and BMI in pregnant women referred to our Department.Methods: We studied 520 women during 24th – 32nd gestation week. De...

Primary Paraganglioma of Thyroid Gland is an extremely rare neuroendocrine tumor. Less than 50 cases have been reported up to date and its rarity is the reason why it’s often mistaken for thyroid nodule or other thyroid neoplasms. In this case we describe the misleading results of ultrasonography followed by FNA-biopsy, which led to a total delay of two years until final diagnosis. A 60 year old female presented with a 38 mm right-sided thyroid module. An ultrasound guide...

Aim: Postoperative calcitonin (postCT) is a prognostic factor for disease progression in MTC patients. We evaluated the disease course in patients with persistently elevated post-CT.Methods: Of all MTC patients (n=273) followed-up in our Unit (for 1–37, median 7 years), 140 (39.3% men, 67.1% sporadicMTCs) had persistently elevated postCT (≥2.0 pg/ml). Clinical and biochemical data were recorded. Patients were classified in four groups...